The aim of this study is to evaluate, versus placebo, the analgesic efficacy of the opercular-insular cortex stimulation with Transcranial Direct Current Stimulation (tDCS), in both healthy subjects and chronic neuropathic pain patients. In healthy subjects analgesia by tDCS will be assessed using both laser stimuli and cold pressor test. In patients the assessment regards their chronic pain (ratings for ongoing, evoked and paroxysmal pain, sleep and fatigue). Opercular-insular stimulation is obtained via a combined 6-electrode montage and by bi-vestibular stimulation (since vestibular pathways reach the posterior insular cortex). In patients, three separate conditions (two active and one sham) will be tested in randomised order. In healthy subjects, two other conditions are added to control for attention and distraction confounders.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
24
transcranial direct current stimulations of opercular-insular cortex. Three sessions separated by a minimum of 2 weeks, with three different conditions: one session with anodal active tDCS, one with active control, and one with sham control.
transcranial direct current stimulations of opercular-insular cortex. Three sessions separated by a minimum of 2 weeks, with three different conditions: one session with anodal active tDCS, one with active control, and one with sham control.
transcranial direct current stimulations of opercular-insular cortex. Three sessions separated by a minimum of 2 weeks, with three different conditions: one session with anodal active tDCS, one with active control, and one with sham control.
Hospices Civils de Lyon - NeuroPain lab - CRNL
Bron, France
In healthy subjects : Change in subjective pain and (when applicable) in cortical evoked potentials with pain scale
Time frame: just before the tDCS session at Day 0
In patients : Changes in daily ratings of global pain
Time frame: just before the tDCS session at Day 0
In healthy subjects : Change in subjective pain and (when applicable) in cortical evoked potentials
Time frame: just after the tDCS session at Day 0
In patients : Changes in daily ratings of global pain
Time frame: just after the tDCS session at Day 0
In patients : Changes in daily ratings of global pain
Time frame: at week 1
ongoing pain with pain scale
Time frame: just before the tDCS session at Day 0
ongoing pain with pain scale
Time frame: just after the tDCS session at Day 0
ongoing pain as assessed by daily ratings
Time frame: during one week
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.