Induction Chemotherapy Followed by Radiotherapy Alone or Concurrent Chemoradiotherapy in Nasopharyngeal Carcinoma

Inclusion Criteria: 1. Patients with newly histologically confirmed non-keratinizing carcinoma. 2. Tumor staged as N2-3 or T3-4 (according to the 7th AJCC staging system) 3. No evidence of distant metastasis (M0) 4. Performance status: KPS\>70 5. With normal liver function test (ALT, AST \<1.5ULN) 6. Renal: creatinine clearance \>60ml/min 7. Without hematopathy,marrow: WBC \>4\*109/L, HGB\>80G/L, and PLT\>100\*109/L. 8. With controlled blood glucose for diabetes patients 9. Written informed consent 10. satisfactory tumor response (complete response or partial response) after neoadjuvant chemotherapy (NACT) Exclusion Criteria: 1. WHO type I squamous cell carcinoma or adenocarcinoma 2. Age \>65 or \<18 3. With a history of renal disease 4. Prior malignancy (except adequately treated carcinoma in-situ of the cervix or basal/squamous cell carcinoma of the skin) 5. Previous chemotherapy or radiotherapy (except non-melanomatous skin cancers outside the intended RT treatment volume) 6. Patient is pregnant or lactating 7. Peripheral neuropathy 8. Emotional disturbance