This study tries to identify the safe and effective treatment option for IgA nephropathy in children. Investigators will perform prospective registration study among 25 pediatric nephrology medical centers in China.
A total of 1200 patients diagnosed as primary IgA nephropathy with nephrotic proteinuria will be enrolled among 25 pediatric nephrology medical centers nationwide, according to the following protocol. 1. Establishment of registration database online. 2. Participants will be enrolled according to the inclusion criteria and exclusion criteria. 3. The following data will be collected prospectively, including demographic data, clinical symptoms, physical examination, laboratory examination, renal pathology, treatment protocol and follow-up. 4. SPSS software (version 14.0; SPSS, Inc., Chicago, IL, USA) will be used for statistical analysis. P value less than 0.05 will be considered significant.
Study Type
OBSERVATIONAL
Enrollment
1,200
Peking University First Hospital
Beijing, China
RECRUITINGImprovement of proteinuria
Complete remission is defined as 24-hour urine protein\<150mg or UPC\<0.3 g/g with normal kidney function. Partial remission is defined as urine protein decreased by more than 50% with normal renal function.
Time frame: Two years
Renal dysfunction
Renal dysfunction is defined as eGFR declined by more than 50%.
Time frame: Two years
Hypertension
Hypertension is defined as blood pressure higher than age-specific average level. Use of antihypertensive drugs will be recorded.
Time frame: Two years
End stage renal disease(ESRD)
ESRD is defined as eGFR\<15ml/min/1.73m2, initiation of long-term dialysis or kidney transplant.
Time frame: Two years
Mortality
Death of participants will be recorded.
Time frame: Two years
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