Volumetric Study of Fat Resorption After Breast Lipofilling

University of Malaya10 enrolled

Overview

Prospective observational study to evaluate effects on washing to improve viability of fat grafts in breast lipofilling.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cosmetic Techniques Mammaplasty

Interventions

Technique of Breast LipofillingPROCEDURE

1. Identification of the donor site Procedure carried out in single sessions under GA. Abdominal site identified and outlined with a skin marker. 2. Fat Harvesting Berlin autologous lipotransplantation technique used according to the BEAULI protocol described by Ueberreiter et al. Infiltration solution -"Klein'solution" contains 1 cc of epinephrine (1:500,000) diluted in 500 cc of 0.001% lactate ringer solution (LRS). 3. Fat Processing After aspiration of nonviable components of the aspirate, fat graft washed using Lactate Ringer Solution for three times. The fat processing and washing were performed by the same assistant for all patients. 4. Fat Transfer (Injection) Fat is injected in small amounts as the needle is gradually withdrawn. Periglandular planes and intrapectoral planes are used. Intraparenchymal injection avoided.

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with breast defect post breast surgery and unsatisfied. The first lipofilling procedure delayed for at least 9 months after the completion of radiotherapy. Patient on chemotherapy deferred until at least 6 month of last chemotherapy. Exclusion Criteria: * Patients are excluded if they experienced local recurrence or distant metastasis

Locations (1)

University Malaya Medical Centre

Lembah Pantai, Kuala Lumpur, Malaysia

Outcomes

Primary Outcomes

Measure fat graft resorption rate after washing with buffered lactate by volumeric MRI imaging

MRI Breast performed before the first lipofilling session, at 1st and 6th months after the lipofilling procedure. Volume measurement performed using OsiriX (v7.0.3, 64 bit , Pixmeo c)

Time frame: 6 month after breast lipofilling

Secondary Outcomes

Confounding factors

To identify confounding factors that affect fat resorption rate in breast lipofilling To evaluate the fat resorption following breast lipofilling with volumetric MRI imaging

Time frame: 6 month after breast lipofilling

Data from ClinicalTrials.gov

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