The purpose of this study is to test whether two new cognitive "stress tests" may help distinguish between people at lower or higher genetic risk of Alzheimer's Disease. The investigators are trying to understand how these cognitive "stress tests" work in people who have not been diagnosed with Alzheimer's Disease and are not exhibiting symptoms of Alzheimer's Disease. Study subjects will undergo testing of memory and executive function during functional magnetic resonance image (fMRI) of the brain and also during a walking test.
The objective is to establish the feasibility and evaluate the role of two novel tests of cognitive resilience for use in identification of early Alzheimer's Disease. The investigators hypothesize that exposure to the controlled stressor of increased cognitive task demand will evoke measurable phenotypes of poor resilience, which will be associated with Alzheimer's Disease risk. The study will include 30 volunteer participants from the Duke Alzheimer's Disease Prevention Registry (ADPR). The ADPR cohort has been characterized according to genetic risk based on genotype at loci associated with Alzheimer's Disease. The investigators will recruit a sample from the ADPR that includes 15 people in the "genetic high risk" group and 15 people, matched by age, in the "genetic low risk" group. Investigators and experimenters are masked to the genetic profile of all participants. All participants will undergo two cognitive stress test protocols. Both protocols include memory and executive function components, one done during functional MRI and one while ambulating on a force sensor mat. Both cognitive stress tests are minimal risk; the primary risk of this study is loss of confidentiality. Genetic testing is not performed as part of this protocol; the sampling strategy will make use of prior genetic testing results, which are not revealed to the primary investigators. In addition to determining whether scores on the two novel tests statistically differ by AD risk groups, the project will establish the tests' feasibility and characteristics for use in future study.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
TRIPLE
Enrollment
29
Subjects will undergo progressively more complex cognitive stress tests that assess memory and executive function while undergoing fMRI.
Subjects will undergo progressively more complex cognitive stress tests that assess memory and executive function both in sitting and while ambulating on a force sensor mat.
Duke University Medical Center
Durham, North Carolina, United States
Change in reaction time during memory testing during fMRI
The primary dependent variable will be change in reaction time when comparing a neutral memory task to a stress condition. Reaction time will be in ms and will be recorded while the subject is undergoing fMRI.
Time frame: Measured immediately during one hour fMRI
Change in reaction time during executive function testing during fMRI
The primary dependent variable will be change in reaction time when comparing a neutral executive function task to a stress condition. Reaction time will be in ms and will be recorded while the subject is undergoing fMRI.
Time frame: Measured immediately during one hour fMRI
Change in accuracy during memory testing during gait task
The primary dependent variable will be DTEcog = (Dual task \[cognitive score\] - Single Task \[cognitive score\] / Single task \[cognitive score\]. For the memory task, the primary cognitive measure will be the number of correct responses.
Time frame: Measured immediately during one hour gait session
Change in reaction time during executive function testing during gait task
The primary dependent variable will be DTEcog = (Dual task \[cognitive score\] - Single Task \[cognitive score\] / Single task \[cognitive score\]. For the executive task, the primary cognitive measure in the DTEcog calculation will be reaction time.
Time frame: Measured immediately during one hour gait session
Change in accuracy during memory testing during fMRI
Secondary dependent variables are accuracy (% correct) when comparing a neutral memory task to a stress condition.
Time frame: Measured immediately during one hour fMRI
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Change in accuracy during executive function testing during fMRI
Secondary dependent variables are accuracy (% correct) when comparing a neutral memory task to a stress condition.
Time frame: Measured immediately during one hour fMRI
Brain activation during memory testing during fMRI
Group differences in brain activation provoked by the memory stress condition will be assessed using brain maps that compare block-average BOLD signal for resting vs neutral task, resting vs stress task, neutral vs stress task.
Time frame: Measured immediately during one hour fMRI
Brain activation during executive function testing during fMRI
Group differences in brain activation provoked by the executive function stress condition will be assessed using brain maps that compare block-average BOLD signal for resting vs neutral task, resting vs stress task, neutral vs stress task.
Time frame: Measured immediately during one hour fMRI
Change in gait performance provoked by memory dual tasking
The secondary dependent variable will be DTEmob = (Dual task\[mobility score\] - Single Task\[mobility score\] / Single task \[mobility score\]. For both memory and executive tasks, the mobility measure in the DTEmob calculation will be gait speed.
Time frame: Measured immediately during one hour gait session
Change in gait performance provoked by executive function dual tasking
The secondary dependent variable will be DTEmob = (Dual task\[mobility score\] - Single Task\[mobility score\] / Single task \[mobility score\]. For both memory and executive tasks, the mobility measure in the DTEmob calculation will be gait speed.
Time frame: Measured immediately during one hour gait session