The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor

Inclusion Criteria: 1. Ability to understand and the willingness to sign a written informed consent document 2. Age≥ 18 and≤ 75 years 3. Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion \> 4mm in preoperative assessment 4. In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection 5. KPS≥ 70 6. Normal bone marrow reserve function and normal liver, kidney function 7. Expected survival period≥ 6 months Exclusion Criteria: 1. Inability to provide an informed consent 2. Evidence of oral distant metastasis or other malignancies 3. The patient has received prior surgery for primary tumor or lymph node ( except for biopsy ) 4. Prior radiotherapy for primary tumor 5. The patient has previously received anti-tumor biological targeted therapy 6. The patient has received chemotherapy or immunotherapy for primary tumors 7. Prior malignancy within the previous 5 years (except for cured skin basal cell carcinoma or cervical carcinoma in situ) 8. With 3-4 grad Allergy to any drug in the treatment 9. Peripheral neuropathy\> 1 grade 10. Any unstable systematic disease (including active infection, uncontrolled high blood pressure, unstable angina, onset of angina within the last 3 months, congestive heart failure, myocardial infarction within the previous 12 months, severe arrhythmia needing drug treatment, liver, kidney or metabolic disease) 11. HIV positive 12. Chronic diseases requiring immune agents or hormone therapy 13. Pregnant or lactating women 14. Drug/alcohol abuse, psychological or spiritual illness that may interfere compliance to the study 15. Patients with epilepsy requiring medications (such as steroids or antiepileptic drugs) 16. The patient has participated in other experimental therapy studies within 30 days 17. Researchers believe that the situation is unsuitable for participation in the group