The Role of Aldosterone in Circulatory Disorders Within Type 2 Diabetes

University of Southern Denmark27 enrolled

Overview

The importance of Aldosterone for endothelial function and Insulin resistance observed within patients with type 2 diabetes

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Endothelial Dysfunction Insulin Resistance

Interventions

EplerenoneDRUG

Eligibility

Sex: ALLMin age: 40 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed diabetic \< 5 Yrs. * BMI \< 32 kg/m2 * Non-smoking * Blood pressure \< 140/90 mmHg (treatment with maximum of two antihypertensive drugs) Exclusion Criteria: * Insulin treatment * Hypertension (\>140/90 mmHg) * Sequelae to diabetes * Smoking * Known chronic diseases * Pregnancy or birth within 3 month * Alcohol misuse

Locations (1)

Cardiovascular and Renal Research

Odense, Denmark

Outcomes

Primary Outcomes

Vascular function

Femoral arterial blood flow in response to femoral arterially infused ACh

Time frame: 8 weeks

Insulin sensitivity measured by a insulin clamp

Glucose infusion rate during euglycaemic-hyperinsulinaemic clamp

Time frame: 8 weeks

Secondary Outcomes

Vascular function

Microperfusion performed on blood vessels in vitro obtained from muscle biopsies

Time frame: 8 weeks

Data from ClinicalTrials.gov

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