The Effect of HMG-CoA Reductase Inhibition on Postprandial GLP-1 Secretion

Inclusion Criteria: * Body mass index (BMI) \>18.5 kg/m2 and \<35 kg/m2 * Caucasian ethnicity * Normal haemoglobin * Glycated haemoglobin (HbA1c) \<43 mmol/mol * Fasting plasma glucose \<6 mmol/l * Informed and written consent Exclusion Criteria: * Diabetes * First-degree relatives with diabetes (both type 1 diabetes and type 2 diabetes) * Liver disease (serum alanine aminotransferase (ALAT) and/or serum aspartate aminotransferase (ASAT) \>2 times normal values) or history of hepatobiliary disorder * Gastrointestinal disease, previous intestinal resection, cholecystectomy or any major intra-abdominal surgery * Reduced kidney function or nephropathy (estimated glomerular filtration rate (eGFR) \<60 ml/min/1.73 m2 (based on serum creatinine) and/or albuminuria * Taking any kind of medicine on a regular basis * Intake of antibiotics two months prior to study * Active or recent malignant disease * Any treatment or condition requiring acute or sub-acute medical or surgical intervention * Any condition considered incompatible with participation by the investigators * If the subjects receive any antibiotic treatment while included in the study they will be excluded