Chronic functional constipation is a common digestive system disease, the incidence is increasing in recent years.It is reported that the occurrence and development of chronic functional constipation is closely related to imbalance of intestinal flora .Moreover,types and quantity of intestinal flora may be related to intestinal motility. Fecal microbiota transplantation as a new technology to rebuild intestinal flora has been used for several disease，but the clinical efficacy of chronic functional constipation by fecal microbiota transplantation needs to be further explored.
Patients who meet the inclusion crit chronic functional constipation will be separated into two parts depending on acceptation or refuse of Fecal microbiota transplantation.Blood specimen from patients will be collected to analysis intestinal motility.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Fecal Microbiota Transplantation and the traditional treatments for chronic functional constipation in part 1.
Normal saline and the traditional treatments for chronic functional constipation in part 2
IEC of Chengdu Medical College
Chendu, China
RECRUITINGNumber of adverse events complication rate in all patients in both groups
Time frame: 3 months
Mean number of bowel movements per week
Time frame: 4 weeks
Bristol stool scale
Time frame: 4 weeks
Constipation-related symptoms assessments
Constipation-related symptoms were evaluated using the validated Patient Assessment of Constipation Symptoms (PAC-SYM) questionnaire at week 4.
Time frame: 4 weeks
Usage of laxatives or enemas as rescue medication
Time frame: 4 weeks
Histological changes in the intestinal biopsy in both groups.
Time frame: 4 weeks
Microbiota composition
Time frame: 4 weeks
Nitric oxide(NO)
Time frame: 4 weeks
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