A poor therapeutic observance is described between 3 and 76% cases in systemic lupus. It is associated with an increased risk of relapses, hospitalizations, morbidity and poor renal prognosis. New treatment protocols exist and are indicated in second intention in case of good compliance. An assessment of therapeutic adherence is therefore essential. Patients with systemic lupus diagnosed for at least 6 months, or skin lupus, who have been prescribed with Plaquenil (hydroxychloroquine), will be included in the study. The study primary objective is to determine risk factors for non-observance The secondary objectives are to: * Measure the observance rate of patients with systemic lupus in Martinique. * Describe the parameters that influence observance: evaluation of the disease and associated comorbidities, psychosocial assessment, assessment of the doctor-patient relationship, evaluation of the disease representations.
Study Type
OBSERVATIONAL
Enrollment
200
Blood sample from a 6 ml tube, performed in the common practice.
CHU de Martinique
Fort-de-France, Martinique, France
The primary outcome measure is based on a blood dosage of hydroxychloroquine (HCQ)
The HCQ dosage is assayed on whole blood (6ml) by high-pressure liquid chromatography performance, reproducible and inexpensive method. Only one laboratory centralizes the sampling. A dosage below 200 ng/ml or 0.2 mg/l defines a non-observing patient within the 40 days above.
Time frame: Reflects the Plaquenil intake during the 40 previous days
Patients considered as observing and non-observing will be compared according to the activity of the disease
Activity of the disease : Systemic lupus considered as active for a SELENA-SLEDAI score ≥ 6
Time frame: 40 days
Patients considered as observing and non-observing will be compared according to number of prescribed medication
Time frame: 40 days
Patients considered as observing and non-observing will be compared according to the presence of anxiety and/or depressive disorders
Presence of anxiety and/or depressive disorders, according to the Hospital Anxiety And Depression Scale (HAD), a score \> to 10
Time frame: 40 days
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