Effect of Magnesium Sulphate on Neostigmine

N/AUnknownNCT03020706

Gachon University Gil Medical Center166 enrolled

Overview

The purpose of this study is to evaluate the effect of magnesium sulphate on neostigmine-induced reversal of neuromuscular block by rocuronium

Comparison of reversa time by neostigmine in magnesium group and control group

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

166

Conditions

Neuromuscular Blockade

Interventions

Magnesium Sulfate, InjectableDRUG

magnesium sulphate intravenous administration during general anesthesia

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ASA status 1 or 2 * patients undergoing surgery for more than 60 min under general anesthesia Exclusion Criteria: * electrolyte abnormalities * medication on aminoglycoside, antiepileptic drug, magnesium * underweight or obesity (BMI \<18.5 or \>30) * renal insufficiency (Cr\>1.4 mg/dl) * AV block * neuromuscular disease (ex: Myathenia gravis)

Locations (1)

Seoul National University Bundang Hospital

Seongnam, Kyungi-do, South Korea

RECRUITING

Outcomes

Primary Outcomes

reversal time

reversal time: from neostigmine injection to TOF ratio 0.9

Time frame: through study completion, an average of 90 minutes

Central Contacts

Hee-Yeon Park, MD

CONTACT

+82 10 3360 0790 hypark@gilhospital.com

Sang-Hwan Do, MD, Ph D

CONTACT

shdo@snu.ac.kr

Data from ClinicalTrials.gov

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