Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients

N/ACompletedNCT03020862

University of Aarhus15 enrolled

Overview

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) using the 6-minute walk test (6MWT) after supplementing with higher doses of dietary NO3- compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease Moderate

Interventions

Dietary beetroot juiceDIETARY_SUPPLEMENT

Consumed as concentrated beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Moderate-severe Chronics Obstructive Pulmonary Disease (COPD) (FEV1 \<80% of predicted). Exclusion Criteria: * Smoking, * failure to complete physical testing, * on-going participation in rehabilitation programs, * pacemaker or use of nicotine products, * oxygen mask, * beta blockers, * antibacterial mouthwash, * chewing gum or stomach-neutralizing medicine during the intervention.

Locations (1)

Sport Science, Department of Public Health, Aarhus University

Aarhus, Denmark

Outcomes

Primary Outcomes

Physical performance on 6-min walk test (6MWT)

Time frame: 6 minutes

Secondary Outcomes

Blood Pressure

Time frame: At baseline and 150 minutes after consumption of beverages

Plasma Nitrite concentration

Time frame: Baseline, 150 and 210 minutes after consumption of beverages

Oxygen consumption during submaximal cycling

Time frame: Two trials of 6 minutes duration (10 min break between trials)

Physical activity level

Measured all intervention days except on the day of testing

Time frame: Six days

Data from ClinicalTrials.gov

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