Comparison Efficacy of 14-day Concomitant Therapy:Clarithromycin vs.Levofloxacin in Eradication of H.Pylori

Inclusion Criteria: -Patients are aged greater than 18 years old who have H. pylori infection diagnosed by any of following three methods: I-Positive rapid urease test (CLOtest). II-Histologic evidence of H. pylori by modified Giemsa staining. III-Positive 13C-urea breath test. without prior eradication therapy and are willing to receive therapy. Exclusion Criteria: * Children and teenagers aged less than 18 years. * Previous eradication treatment for H. pylori. * Patients who took any drug, which could influence the study results such as proton pump inhibitor, H2 blocker, mucosal protective agent and antibiotics. * History of gastrectomy. * Gastric malignancy, including adenocarcinoma and lymphoma, * Previous allergic reaction to antibiotics (Amoxicillin, Tinidazole , Levofloxacin) and prompt pump inhibitors (Es-omeprazole). * Contraindication to treatment drugs. * Pregnant or lactating women. * Severe concurrent disease. Liver cirrhosis. Chronic kidney disease. * Patients who cannot give informed consent by himself or herself.