L-carnitine Corrects Ammonia Metabolism in Hepatectomized Patients

Kochi University80 enrolled

Overview

L-carnitine is synthesized from lysine and methionine. Postmortem concentrations of carnitine in liver, muscle, heart, kidney, and brain averaged only one-fourth to one-third those in corresponding tissues of eight normally nourished non-hepatic patients who died after an acute illness of a 1-3-day duration. In the recent years, it has been reported that sirtuin 3 (SIRT3) is protective against acute kidney injury (AKI) and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury. In the current study, it is the first clinical interventional research whether L-carnitine corrects ammonia metabolism associated with liver injury in hepatectomized patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Ammonia Metabolism

Interventions

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients were those surgically treated for hepato-biliary diseases Exclusion Criteria: * Patient exclusion criteria included a body weight loss greater than 10% during the six months prior to surgery, the presence of distant metastases, or seriously impaired function of vital organs due to respiratory, renal or heart disease.

Outcomes

Primary Outcomes

postoperative ammonia levels

change from preoperative baseline at postoperative day 1 and day3

Time frame: 3 points; preoperative baseline, postoperative day 1, and day3

Secondary Outcomes

length of hospitalization after liver resection

postoperative days

Time frame: up to 24 weeks