Blue Light Photodynamic Therapy Treatment for Distal and Lateral Subungual Toenail Onychomycosis

Inclusion Criteria: * Patients older than 19 and younger than 70 years * Give written informed consent prior to any study procedures being conducted, and candidates will authorize the release and use of protected health information (PHI) * Diagnosed with distal lateral subungual onychomycosis (DLSO) of the great toe with both positive potassium hydroxide (KOH) and positive culture growth of Trichophyton rubrum * No topical treatment for DLSO in the preceding 2 weeks and no oral treatment for DLSO (itraconazole or terbinafine) in the preceding 8 weeks * At lease 20% of target great toe nail affected Exclusion Criteria: * Unable to comply with the protocol (as defined y the investigator; i.e. drug or alcohol abuse or history of noncompliance) * Patients with active nail disease that would confound evaluation of DLSO, such as psoriasis * Patients with greater than 6 toenails affected * Over 90% of target great toe affected * Evidence of fingernail fungal infection * Patients with recurrent serious infections or have been hospitalized in the preceding 6 months for infection * Patients with known history of HIV or hepatitis B or C infection * Patients with severe, progressive, or uncontrolled with renal, hepatic, hematological, gastrointestinal, metabolic, endocrine, pulmonary, cardiovascular, or neurologic disease * Any subject who, in the opinion of the investigator, will be uncooperative or unable to comply with study procedures