Recently revised Alzheimer Disease (AD) diagnostic1described nonamnestic presentations: 1/ language presentation (logopenic progressive aphasia) 2/ visuospatial presentation (posterior cortical atrophy or PCA) and 3/ executive dysfunction. AD pathological changes may precede the clinical diagnosis of dementia of AD type for a while2. Biomarkers have been developed: biomarkers of brain amyloid-beta (Aß) (CerebroSpinal Fluid CSF concentration ßamyloid, molecular imaging with amyloid targeted PET ligands), biomarkers of neural degeneration (MRI hippocampal volume, regional metabolism as assessed by PET with \[18F\]-FDG) and may be used to made early detection of the neuropathology associated with AD Even if CSF biomarkers (tau, p-tau and β amyloïd are interesting to improve diagnosis of AD, they cannot provide topographic information. PET tau imaging seems to be promise to evaluate quantitative and spatial assessment of tau lesions both in AD and fronto-temporal lobar dementia. The hypothesis of the research is that it exists a different regional pattern of tracer retention across brain regions according to clinical symptoms : temporal for logopenic aphasia and occipital for posterior cortical atrophy.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
17
Imaging with \[18F\]T807 PET
University Hospital of Tours
Tours, France
Tau density on PET imaging
density pattern of aggregated tau using tau targeting PET imaging with \[18F\]-T807, in Standardized uptake value (SUV)
Time frame: 3 months
Tau distribution on PET imaging
distribution pattern of aggregated tau using tau targeting PET imaging with \[18F\]-T807, in Standardized uptake value (SUV)
Time frame: 3 months
p-tau CSF biomarkers
p-tau dosing in pg/mL
Time frame: inclusion
βamyloid CSF biomarkers
βamyloid dosing in pg/mL
Time frame: inclusion
Cognitive profile with Hamilton depression scale (MADRS)
neuropsychological score of Hamilton depression scale (MADRS) on 30 points.
Time frame: inclusion
Cognitive profile with Mini mental state evaluation (MMSE)
neuropsychological score of Mini mental state evaluation (MMSE) on 60 points
Time frame: inclusion
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