The goal of this proposed intervention study is to increase the proportion of HIV positive and HIV negative pregnant women who deliver in a facility, the proportion of HIV exposed infants (HEI) who receive nevirapine (NVP) within 48 hours of delivery, and the proportion of HEI who are bled for HIV polymerase chain reaction (PCR) deoxyribonucleic acid (DNA) testing within 8 weeks of age.
Following a formative phase I, we propose in phase II to implement a three-group cluster-randomized study to test the effectiveness of short message service (SMS) reminders and notifications, \[mobile health or mhealth\] (group 1) and the combined effectiveness of SMS reminders/notifications and cash transfers (group 2) compared to the standard prevention of mother-to-child transmission (of HIV)/maternal, neonatal and child health, (PMTCT/MNCH) practices (group 3).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
1,505
SMS appointment reminders and health messaging via mobile phones
A payment scaled to reflect the cost of typical return transport fare for residents of the clinic catchment area
Elizabeth Glaser Pediatric AIDS Foundation
Dar es Salaam, Tanzania
Attendance for Early infant diagnosis (EID) of HIV
Proportion of HIV-exposed infants (HEI) attending for early infant diagnosis of HIV (DBS collected) by 8 weeks
Time frame: 1 year
Early identification of HEI at Reproductive and Child Health (RCH) Clinic
Proportion of HEI identified early (48 hours,3 and 7 days) at RCH clinic
Time frame: 1 year
Antenatal care (ANC) visits
Proportion of pregnant women attending at least 4 ANC visits
Time frame: 1 year
Facility delivery
Proportion of pregnant women delivering in a health facility
Time frame: 1 year
Post natal care (PNC) visits
Proportion of post partum women attending PNC 48 hours, 3 and 7 days post delivery
Time frame: 1 year
Nevirapine (NVP) at delivery
Proportion of HEI given NVP at delivery
Time frame: 1 year
Receipt of EID results
Proportion of HEI who received EID results by 12 weeks
Time frame: 1 year
HIV infected infants initiated on antiretroviral therapy (ART)
Proportion of HIV infected infants initiated on ART by 12 weeks of age
Time frame: 1 year
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Time to EID
Time (days/weeks) from date of birth to attendance for EID
Time frame: 1 year
Time to receipt of EID results
Time (days/weeks) from date of birth to receipt of EID results
Time frame: 1 year
Time to treatment
Time (days/weeks) from date of birth to initiation of ART
Time frame: ! year