Diagnosis of Bladder Pain Syndrome / Interstitial Cystitis

Cantonal Hospital, Frauenfeld300 enrolled

Overview

To identify new, simple and reliable biomarkers for bladder pain syndrome/interstitial cystitis (BPS/IC) for diagnosis of this disease.

Collection and analyses of bladder biopsies, bladder washings, blood and urine samples of patients with bladder pain syndrome/interstitial cystitis (BPS/IC), overactive bladder syndrome (OAB) and bladder-healthy controls. Analyses include ELISA, RT-qPCR, DNA sequencing, and immunohistochemistry techniques. Differences between patient groups are statistically evaluated.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

300

Conditions

Bladder Pain Syndrome Interstitial Cystitis Overactive Bladder

Interventions

biopsyPROCEDURE

cold cup bladder biopsies and bladder washings under anesthesia, blood and urine collection

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient with diagnosed BPS/IC, OAB or healthy controls * included healthy controls must have another pelvic surgery planned (e.g. hysterectomy) * being able to act and judge Exclusion Criteria: * unstable endocrinological situation * severe illness

Locations (1)

Cantonal Hospital Frauenfeld

Frauenfeld, Thurgau, Switzerland

Outcomes

Primary Outcomes

Identification of new diagnostic markers for BPS/IC

Time frame: 2 days

Secondary Outcomes

Identification of molecular details that lead to BPS/IC (pathogenesis).

Time frame: 2 days

Data from ClinicalTrials.gov

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