Cognitive remediation (CR) is the best treatment to improve neurocognitive abilities for individuals with psychosis, however, there is no gold standard method of cognitive remediation available. Cognitive training refers to the training component of CR in which people practice computerized exercises that train specific cognitive abilities. There is no agreed upon approach within the field as to the type of training that is most effective with some studies, training higher level cognitive abilities, some training perceptual abilities, and others training general cognitive skills. This study will directly compare two competing methods of cognitive training on measures of neurophysiology, neurocognition, functional competence, and real-world functional performance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
70
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as memory, and problem solving ability.
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as attention, and processing speed.
Queen's University
Kingston, Ontario, Canada
Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline
Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks
Time frame: Post-treatment (within 2 weeks following the end of treatment)
Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline
The MCCB is the gold standard cognitive assessment for schizophrenia research
Time frame: Post-treatment (within 2 weeks following the end of treatment)
Change in Neurophysiology - EEG from Baseline
Alpha and Theta band synchronization, p300, mismatch negativity
Time frame: Post-treatment (within 2 weeks following the end of treatment)
Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline
Performance based measure of real life functional skills using role-play
Time frame: Post-treatment (within 2 weeks following the end of treatment)
Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline
Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks
Time frame: Follow-Up (3 months after the end of treatment)
Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline
The MCCB is the gold standard cognitive assessment for schizophrenia research
Time frame: Follow-Up (3 months after the end of treatment)
Change in Neurophysiology - EEG from Baseline
Alpha and Theta band synchronization, p300, mismatch negativity
Time frame: Follow-Up (3 months after the end of treatment)
Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline
Performance based measure of real life functional skills using role-play
Time frame: Follow-Up (3 months after the end of treatment)
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