Metabolomics in Assessing the Quality of Kidney Transplants Retained on a LifePort® Perfusion Machine

University Hospital, Tours40 enrolled

Overview

When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.

The quality of the renal transplant prior to transplantation is essential for the recovery of graft function in the days following transplantation and its long-term survival. When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Renal Transplantation

Interventions

LifePort® perfusion machineDEVICE

Renal perfusion on LifePort® machine

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Donors aged 18 years or more in brain death or who died of cardiac arrest collected locally in Tours, associated with the major local recipients of the grafts over the same period. Exclusion Criteria: * Kidney transplant removed but stored in a static preservative. * Kidney grafts of donors aged 18 years or more, removed and not retained on a LifePort® perfusion machine.

Locations (2)

Urology CHRU-TOURS

Tours, I&L, France

CHR-ORLEANS Service d'Urologie

Orléans, Loiret, France

Outcomes

Primary Outcomes

IGF

Immediate Graft Function (IGF), defined by serum creatinine less than 250 μM / L at day 7 post-kidney transplant, without requiring dialysis of the recipient patient.

Time frame: 7 days

Secondary Outcomes

DGF

DGF Delayed graft function : Dialysis need within 7 days post-transplant

Time frame: 7 days

BANFF-1

Anatomo-pathological classification of the pre-implantation biopsy according to the revised Banff classification 2013

Time frame: PRE-OPERATIONAL

BANFF-2

Anatomo-pathological classification of systematic biopsy at 3 months post-transplant according to the revised Banff classification 2013

Time frame: 3 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.