Randomized Study on Salt Intake and Energy Metabolism

Charite University, Berlin, Germany40 enrolled

Overview

To perform a randomized, double-blind clinical study on the effects of an increased salt intake on metabolic, cardiovascular and immunological parameters and the gut microbiota

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Healthy

Interventions

SaltDIETARY_SUPPLEMENT

10 capsules daily for 14 days

PlaceboDIETARY_SUPPLEMENT

10 capsules daily for 14 days

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women * 18 - 50 years * Body mass index 18.5 - 29.9 kg/m2 Exclusion Criteria: * Clinically relevant heart, lung, liver, and kidney diseases * Current or chronic infection * Habitual use of probiotics or dietary supplements * Pregnancy, lactation

Locations (1)

Experimental and Clinical Research Center

Berlin, Germany

Outcomes

Primary Outcomes

Dietary induced thermogenis (%)

Decrease of dietary induced thermogenis after salt vs. placebo

Time frame: 14 days

Secondary Outcomes

Systolic blood pressure (mmHg)

Increase of systolic blood pressure after salt vs. placebo

Time frame: 14 days

Lymphocytic pro-inflammatory mediators

Increase of lymphocytic pro-inflammatory mediators after salt vs. placebo

Time frame: 14 days

Gut microbiome

Change of gut microbiome composition after salt vs. placebo

Time frame: 14 days

Data from ClinicalTrials.gov

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