The main purpose of this study is to investigate the side effects related to LY3192767 when given as an injection under the skin to healthy participants. Blood tests will be done to check how much LY3192767 is absorbed into the bloodstream, how long it takes for the body to get rid of it, and how it affects blood sugar levels. The study has two parts: Part A and Part B. Each participant will enroll in one part. For each participant, Part A will last up to about 32 days after last dose and Part B will last up to about 49 days after last dose. Screening must be completed prior to study start.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
57
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri, 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician.
Neuss, North Rhine-Westphalia, Germany
Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
A summary of SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module
Time frame: Baseline through Study Completion (up to about Day 49)
Pharmacokinetics (PK): Time to Maximum Concentration (Tmax) of LY3192767
PK: Tmax of LY3192767
Time frame: Predose through 336 Hours
PK: Maximum Serum Concentration (Cmax) of LY3192767
PK: Cmax of LY3192767
Time frame: Predose through 336 Hours
PK: Area Under the Concentration-Time Curve from Time Zero to Infinity (AUC[0-inf] of LY3192767
PK: AUC(0-inf) of LY3192767
Time frame: Predose through 336 Hours
Pharmacodynamics (PD): Total Amount of Glucose Infused (Gtot) of LY3192767
PD: Total Amount of Glucose Infused (Gtot) of LY3192767
Time frame: Predose through 36 Hours During Clamp Procedure
PD: Maximum Glucose Infusion Rate (Rmax) of LY3192767
PD: Rmax of LY3192767
Time frame: Predose through 36 Hours During Clamp Procedure
PD: Time of Maximum Glucose Infusion Rate (TRmax) of LY3192767
PD: TRmax of LY3192767
Time frame: Predose through 36 Hours During Clamp Procedure
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Administered SC.
PD: Change from Baseline in Free Fatty Acids
PD: Change from Baseline in Free Fatty Acids
Time frame: Predose through 48 Hours Postdose
PD: Change from Baseline in Glycerol
PD: Change from Baseline in Glycerol
Time frame: Predose through 48 Hours Postdose
PD: Change from Baseline in Triglycerides
PD: Change from Baseline in Triglycerides
Time frame: Predose through 48 Hours Postdose