The aim of the present proposal is to investigate the development of distinct morphological, functional, biochemical and molecular aspects of short- and long-term sport-induced changes in the heart, to get a better understanding on the (patho)physiology of athlete's heart. The main goal of our research is to deepen our knowledge on the proper differentiation between beneficial (physiological) and harmful (pathological) consequences of professional sport, thereby effectively preventing potential cardiovascular complications of athletes.
CLINICAL METHODS 1. Sport specific questionnaire, patient history and physical examinations - In our detailed questionnaire, specific information is collected about quantity and quality of training, personal and family history and presence of sport specific and general symptoms. 2. Laboratory biochemical examination - Besides the regular routine laboratory parameters, several specific parameters associated with physical exercise are planned to be measured, such as cardiac biomarkers. 3. 12-lead ECG - Resting standard 12-lead digital ECG will be recorded. Extended analysis will be performed according to the latest recommendations. 4. Holter ECG - 24 hour Holter ECG will be recorded. Extended Holter ECG analysis will be performed. 5. Detailed echocardiography 6. Detailed CMR examination 7. Body composition analysis - With a sophisticated bio-electrical impedance analysis, comprehensive whole body composition and hydration analysis will be performed. 8. Cardiopulmonary exercise testing - Sport specific protocols will be used on both treadmill and bike ergometers.
Study Type
OBSERVATIONAL
Enrollment
150
Heart and Vascular Center, Semmelweis University
Budapest, Hungary
RECRUITINGThe primary analysis will be an investigation regarding the athletic adaptation using CMR
Time frame: Baseline
The primary analysis will be an investigation regarding the athletic adaptation using cardiopulmonary exercise testing
Time frame: Baseline
The primary analysis will be an investigation regarding the athletic adaptation using resting ECG
Time frame: Baseline
The primary analysis will be an investigation regarding the athletic adaptation using 24-Hour Holter ECG
Time frame: Baseline
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