A Study to Determine the Safety and Immunogenicity of a Candidate MAP Vaccines ChAdOx2 HAV and MVA in Healthy Adult Volunteers

Inclusion Criteria: 1. Healthy adults aged 18 to 50 years 2. Able and willing (in the Investigator's opinion) to comply with all study requirements 3. Willing to allow the investigators to discuss the volunteer's medical history with their General Practitioner 4. For females only, willingness to practice continuous effective contraception (see below) during the study and a negative pregnancy test on the day(s) of screening and vaccination 5. Agreement to refrain from blood donation during the course of the study 6. Provide written informed consent Exclusion Criteria: 1. Participation in another research study involving receipt of an investigational product in the 30 days preceding enrolment, or planned use during the study period 2. Prior receipt of an investigational vaccine likely to impact on interpretation of the trial data. 3. Prior receipt of an adenoviral vectored vaccine in the last 12 months 4. Administration of immunoglobulins and/or any blood products within the three months preceding the planned administration of the vaccine candidate 5. Any confirmed or suspected immunosuppressive or immunodeficient state, including HIV infection; asplenia; recurrent, severe infections and chronic (more than 14 days) immunosuppressant medication within the past 6 months (inhaled and topical steroids are allowed) 6. History of allergic disease or reactions likely to be exacerbated by any component of the vaccine 7. Any history of hereditary angioedema, acquired angioedema, or idiopathic angioedema. 8. Any history of anaphylaxis in relation to vaccination 9. Pregnancy, lactation or willingness/intention to become pregnant during the study 10. History of cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) 11. History of serious psychiatric condition likely to affect participation in the study 12. Bleeding disorder (eg. Factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following IM injections or venepuncture 13. Any other serious chronic illness requiring hospital specialist supervision 14. Suspected or known current alcohol abuse as defined by an alcohol intake of greater than 42 units every week 15. Suspected or known injecting drug abuse in the 5 years preceding enrolment 16. Seropositive for hepatitis C (antibodies to HCV) 17. Seropositive for hepatitis B surface antigen(HBsAg) 18. Any clinically significant abnormal finding on screening biochemistry or haematology blood tests or urinalysis 19. Any other significant disease, disorder or finding which may significantly increase the risk to the volunteer because of participation in the study, affect the ability of the volunteer to participate in the study or impair interpretation of the study data 20. Inability of the study team to contact the volunteer's GP to confirm medical history and safety to participate.