A large multicentric registry to obtain data to analyse the pulmonary autograft (PA) failure phenomenon and feed more complex biomechanical models to be integrated with clinical imaging with the final aim to predict Ross operation's outcomes and define strategies to ameliorate its results.
On the basis of the current knowledge on the outcomes of Ross Operation we aim to create a large multi centric registry in order to obtain data on the preoperative intraoperative management of these patients and on the postoperative long-term results of this procedure. Patients data will be entered by the investigators in an electronic database Preoperative variables will include age, comorbidities, functional status, indications for surgery, morphology of the aortic valve Additional morphological data and aortic and pulmonary measurements will be taken intraoperatively Postoperative follow-up data including both clinical outcomes (mortality, reoperation for pulmonary autograft failure, major cardiac events, stroke, infection) and morphological measurements by means of CT scan or echocardiography, will be inserted. Quality of life by means of SF12 and Minnesota living with heart failure questionnaire and EQ-5D score will be collected. Follow-up endpoints are at discharge, 1 year 5 years 10 years 15 years and 20 years.
Study Type
OBSERVATIONAL
Replacement of the aortic valve by means of pulmonary artery autograft
Centre Cardiologique Du Nord
Paris, France
Survival
Death from any cause
Time frame: from inclusion to 20 years follow-up
Cardiac Death
Mortality due to cardiac cause
Time frame: from inclusion to 20 years follow-up
Reoperation for Pulmonary Autograft Failure
Need for reoperation due to failure of pulmonary autograft or valve degeneration
Time frame: from inclusion to 20 years follow-up
Stroke
neurological stroke with impairment
Time frame: from inclusion to 20 years follow-up
Rehospitalization for heart failure
Readmission to hospital for heart failure
Time frame: from inclusion to 20 years follow-up
Quality of life-1
Quality of life as measured with SF-12
Time frame: from inclusion to 20 years follow-up
Quality of life-2
Quality of life as measured with Minnesota living with heart failure questionnaire
Time frame: from inclusion to 20 years follow-up
Quality of life-3
Quality of life as measured withEQ 5D score
Time frame: from inclusion to 20 years follow-up
Postoperative complications
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Combined outcome including bleeding, arrhythmia, respiratory failure, renal failure
Time frame: postoperative period (1-30 days)