Postpartum Uterine Curettage in the Recovery From Preeclampsia/Eclampsia

Saint Thomas Hospital, Panama442 enrolled

Overview

Use of Postpartum uterine curettage in reducing hospitalization time or in improving the clinical evolution of the patient with preeclampsia/eclampsia.

To evaluate if postpartum uterine curettage improved the clinical and laboratory parameters in patients with preeclampsia or eclampsia. A total of 442 patients with preeclampsia/eclampsia were randomized to postpartum curettage (223) or no procedure (219). Systolic and diastolic blood pressure were recorded and analyzed at hours 6, 12, 24 and 48. Also, several laboratory values and diuresis were evaluated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

442

Conditions

Pre-Eclampsia Eclampsia

Interventions

CurettagePROCEDURE

Postpartum uterine curettage with a sharp curette # 14 or #16, immediately after delivery of the placenta.

PlaceboPROCEDURE

No procedure after delivery of the placenta

Eligibility

Sex: FEMALEMin age: 15 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Gestational age 24 weeks or more. * Preeclampsia/eclampsia Exclusion Criteria: * Epilepsy or seizures previous to pregnancy. * Renal disease * Heart disease * Liver disease

Locations (2)

Saint Thomas H

Panama City, Provincia de Panamá, Panama

Saint Thomas Maternity Hospital

Panama City, Provincia de Panamá, Panama

Outcomes

Primary Outcomes

Systolic and diastolic blood pressure

Arterial blood pressure

Time frame: 6 hours

Systolic and diastolic blood pressure

Arterial blood pressure

Time frame: 12 hours

Systolic and diastolic blood pressure

Arterial blood pressure

Time frame: 24 hours

Systolic and diastolic blood pressure

Arterial Blood pressure

Time frame: 48 hours

Secondary Outcomes

Laboratory results (hypertensive disorder profile: hemoglobin, hematocrit, platelets, renal or liver function tests).

Number of patients with an abnormal laboratory value

Time frame: 6 hours

Laboratory results (hypertensive disorder profile: hemoglobin, hematocrit, platelets, renal or liver function tests).

Number of patients with an abnormal laboratory value

Time frame: 12 hours

Laboratory results (hypertensive disorder profile: hemoglobin, hematocrit, platelets, renal or liver function tests).

Number of patients with an abnormal laboratory value

Time frame: 24 hours

Laboratory results (hypertensive disorder profile: hemoglobin, hematocrit, platelets, renal or liver function tests).

Number of patients with an abnormal laboratory value

Time frame: 48 hours

Data from ClinicalTrials.gov

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