A 1-year Clinical Investigation on the the CREOS™ XENOGAIN Bone Graft SUBSTITUTE

Inclusion Criteria: * Subjects between 18 and 80 years old. * Patient has signed informed consent to participate in the study. * Patients in need of horizontal ridge augmentation prior to implant placement in the premolar and posterior region of the mandible * Horizontal defect classified as: Horizontal medium defect (Hm) (4-6 mm defect) or Horizontal large defect (Hl) (≥7 mm defect) * Patients presented with a combination defect Horizontal/Vertical with a maximum of 2mm loss of vertical dimensions (minimal vertical dimension for patient inclusion is 7.5 mm defined as the distance from the anatomical landmark, alveolar nerve or lingual dehiscence) * The subject must be in good physical and mental condition * The subject is willing and able to comply with all study related procedures (such as exercising oral hygiene and attending all follow-up procedures). * Full-mouth bleeding score (FMBS) lower than 25%. * Full-mouth plaque score (FMPI) lower than 25%. * The subject is suitable for a 2-stage surgical procedure Exclusion Criteria: * Severe bone defect classified as: Vertical medium (Vm) (4-6 mm defect) or Vertical large, (Vl) (≥7 mm) * Medium (Cm) and Large (Cl) classified combination defects Prior bone augmentation in the area planned for treatment (i.e ridge preservation) * Health conditions, which do not permit the surgical (including anesthesia) or restorative procedure. * Any disorders directly in the planned implant area such as previous tumors, chronic bone disease. * Any ongoing application of interfering medication (steroid therapy, bisphosphonate, etc). * Alcohol or drug abuse as noted in subject records or in subject history. * Reason to believe that the treatment might have a negative effect on the subject's overall situation (psychiatric problems), as noted in subject records or history. * Heavy smoking (\> 10 cigarettes per day). * Uncontrolled diabetes, i.e. a subject with diagnosed diabetes that has a history of neglecting doctor's recommendations regarding treatment, food and alcohol intake or A1c level above 8%. * Poor compliance. * Active periodontal disease involving the residual dentition. * Mucosal diseases in the areas to be treated. * Pregnant or lactating women at the time of bone augmentation procedure.