30 Gy single fraction of SBRT for lung metastases will result in comparable oncologic outcomes to 18Gy in three fractions (or dosing to a BED \</-100Gy at the discretion of the radiation oncologist) with respect to disease control and toxicity.
Using two different doses of SBRT, this study will examine the 6-month local disease control rate (LDCR) of the SBRT-treated metastasis to determine the optimum dosing for SBRT in pulmonary metastases. This will allow us to establish baseline SBRT data, from which we will develop a second trial to examine sequencing of immunotherapy with SBRT.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Stereotactic Body Radiation Therapy using different fractionation schedules
University of Kentucky
Lexington, Kentucky, United States
Local Disease Control Rates
Response defined by the Revised Response Evaluation Criteria in Solid Tumors (RECIST) Guideline version 1.1
Time frame: 6 MONTHS
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