The purpose of the study to evaluate the feasibility of using low dose propranolol for people with fibromyalgia.
The main purpose of this study is to collect pilot feasibility study data for the use of low dose propranolol for helping treat fibromyalgia. The investigators plan to compare 20mg twice a day dosage of propranolol and 10mg twice a day dosage of propranolol to placebo. The design is a 3 arm, double blind randomized control trial. The investigators will also test ECG and respiratory assessment as a part of the safety screening and the feasible assessment of respiratory sinus arrhythmia. Propranolol is not indicated to treat pain. However, the previous studies showed that low dose propranolol can re-regulate the adrenergic dysfunction and reduce pain in people with chronic musculoskeletal pain. However, the investigators are not aiming to develop a new indication of the drug.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
15
Participants will take 20 mg propranolol twice a day for 2 weeks
Participants will take 10 mg propranolol twice a day for 2 weeks
Participants will take placebo twice a day for 2 weeks
University of Utah
Salt Lake City, Utah, United States
Change in self-reported measures of clinical pain using Fibromyalgia Impact Questionnaire - Revised (FIQ-R)
Changes in clinical pain will be measured
Time frame: Pre (one week before start taking propranolol or placebo) and Post (immediately following the 14-day trial)
Change in self-reported measures of Fibromyalgia symptoms using Promis Fatigue
Changes in fibromyalgia-related symptoms
Time frame: Pre (one week before start taking propranolol or placebo) and Post (immediately following the 14-day trial)
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