The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
220
Placebo nasal spray
Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin
Berlin, Germany
Intrusive memories
Influence of oxytocin on the development of intrusive memories measured with an intrusion diary
Time frame: four consecutive days
Noradrenergic System (measured with salivary alpha-amylase - u/ml)
Influence of oxytocin on the noradrenergic system measured with salivary alpha-amylase
Time frame: Day 1
Genetic polymorphism
Influence of genetic polymorphism of the oxytocin receptor on intrusive memories measured with an intrusion diary
Time frame: four consecutive days
Hypothalamic-pituitary-adrenal (HPA) axis (measured with salivary cortisol - nmol/L)
Influence of oxytocin on the HPA-axis measured with salivary cortisol
Time frame: Day 1
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