To evaluate the difference of three vaginal estrogens creams comparative with placebo on improvement of hormonal cytology, local and systemic climacteric complaints, as well as its endometrial security.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
69
Evaluate the histopathological effects on endometrium after each treatment
Compare the histopathological results after treatment on each group and among each other
Time frame: 48 days
Compare the endometrial thickness measured by ultrassound after each treatment
Compare the endometrial ultrasound measurement before and after treatment in each group, and among each other
Time frame: 48 days
Evaluate the changes of maturation index (Meisels Index) after each treatement
Compare the changes on Meisels Index after each treatment and among each other
Time frame: 48 days
Evaluate the changes on climacteric complaints after each treatment
Compare the changes on systemic and genital complaints after each treatment, and among each other
Time frame: 48 days
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use of 1 gram per day