The aim of this prospective, randomized, placebo controlled study is to evaluate the effect of a single preoperative dose of amoxicillin/clavulanic acid combination on post-operative pain and swelling in adult patient with symptomatic apical periodontitis.
Medical and dental history will be obtained from all patients participating in this trial. Clinical and radiographic evaluation for each tooth included in this study will be recorded. Clinical diagnosis of symptomatic apical periodontitis is to be confirmed. Prior to initiation of root canal treatment, eligible participants will be randomly assigned to one of the following groups: experimental group (receiving 2 gm of amoxicillin/ clavulanic acid orally 30 minutes before the treatment) or control group (receiving a placebo 30 minutes before treatment). Root canal treatment will then be carried out in a single visit. Each patient will receive a 7-day diary to record postoperative pain and swelling. In case of pain, the participant will be instructed to take an analgesic. Post-operative pain will be measured as a primary outcome on 11-point scale (NRS) at the following time points: 6, 12, 24, 48, 72 hours and 7 days. The occurrence of swelling will be reported by participant as a secondary outcome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
72
2 gm of amoxicillin/ clavulanic acid combination orally 30 minutes before root canal treatment
placebo 30 minutes before root canal treatment
Cairo University Faculty of Dentistry
Cairo, Egypt
Postoperative pain
Postoperative pain will be measured by a numerical rating scale (NRS).
Time frame: Up to 7 days after endodontic treatment
Swelling
The occurrence of Swelling will be measured by a questionnaire.
Time frame: Up to 7 days after endodontic treatment
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.