Evaluation of Cerebral Oxygenation and Hemodynamics in Patients With Cerebral Venous Thrombosis

Dhritiman Chakrabarti17 enrolled

Overview

Cerebral hypoperfusion and hypoxia are the major determinants of neurological outcomes following acute brain injury as proved in Traumatic Brain Injury/Sub Arachnoid Haemhorrhage literature. How the brain injury affects cerebral oxygenation in patients with CVT is not currently known. Some of the factors that can affect cerebral oxygenation in patients with CVT are Hemoglobin, PO2, PCO2, Cerebral Perfusion Pressure (or MAP) and change in Intracranial Pressure after Decompressive Craniectomy. This study is designed to study how these factors affect cerebral oxygenation and impact of Decompressive Craniectomy on the cerebral oxygenation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cerebral Venous Thrombosis

Interventions

NIRS based Cerebral OximetryDEVICE

Cerebral Oximetric measurement before and after decompressive craniectomy

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: -Patients diagnosed with cerebral venous thrombosis, undergoing decompressive craniectomy. Exclusion Criteria: * Patients on inotropic support * Systolic blood pressure \< 90 mmHg * Haemoglobin oxygen saturation \<95% * Refusal of consent * Age \<16 and \> 65 years * Known history of diabetes or hypertension * Pregnancy * Any contraindication for application of cerebral oximetry sensors

Outcomes

Primary Outcomes

Ipsilateral Regional Cerebral Oxygen Saturation

Measurement of regional cerebral oxygen saturation over ipsilateral frontal lobe before and after decompressive craniectomy with follow up at postoperative 24 and 48 hours.