Gentrix™ Versus Biological or Prosthetic Mesh

Inclusion Criteria: * Male and female patients ≥ 18 years old. * American Society of Anesthesiologists (ASA) physical status classification of I, II, III or IV. * Able to provide informed consent in English or Spanish. * Stated willingness to comply with all study procedures and availability for the duration of the study. * Body Mass Index (BMI) =\< 45. * Incisional hernia from a midline incision ≥ 4 cm in greatest diameter, or any recurrent incisional hernia. Exclusion Criteria: * Any other type of ventral hernia, such as umbilical, epigastric or Spigelian hernia. * Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study, if applicable. * Allergy or hypersensitivity to materials in porcine-based study products, biological or prosthetic meshes, or personal preference. * Contraindications to general anesthesia. * Patient undergoing any emergency surgery prior to treatment. * Severe comorbid conditions likely to limit survival to less than 3 years in the opinion of the Investigator. * Have abdominal loss of domain such that the operation would be impractical or would adversely affect respiratory or cardiovascular function to an unacceptable degree in the opinion of the Investigator. * Inability to close the fascia primarily with abdominal wall mobilization or component separation; confirmed intra-operatively. * History of malignancy within the past 5 years except for non-melanoma skin cancer. * Known active malignancy present and/or had chemotherapy 12 weeks prior to screening or planned chemotherapy within 12 weeks of treatment with exception of basal cell carcinoma, squamous cell carcinoma, or prostate cancer in situ. * Cirrhosis with or without ascites. * Received high dose steroids (\>/=100mg of prednisone) within the past 6 weeks of screening. * Uncontrolled diabetes (i.e. known HbA1C value \> 7% within the prior 6 weeks of the Screening Visit). * History of drug addiction (recreational drugs, prescription drugs or alcohol) that in the Investigator's opinion may interfere with protocol assessments and/or the subject's ability to complete the required follow up. * Serious or active medical or psychiatric condition which, in the opinion of the Investigator, may interfere with treatment, assessment, or compliance with the protocol. * Suspected presence of enterocutaneous fistula. * Planned use of external VAC dressing intra-operatively. * Suspected bowel obstruction (partial or intermittent), strangulation, peritonitis, or perforation. * Active necrotizing fasciitis or any other known active local or systemic infection. * Subject report of participation in an investigational drug or device study that would impact the safety or scientific integrity of this study (in the opinion of the Investigator and with the approval of the Sponsor) within the past 6 weeks prior to treatment in this trial.