Detection of Area of Ischemia in Patients With Subacute Stroke Via a Hybrid EEG-fNIRS Brain-computer Interface

The University of Texas Health Science Center, Houston5 enrolled

Overview

The purpose of this research study is to determine whether a combined electroencephalography (EEG) and functional near infrared spectroscopy (fNIRS) recording is able to detect changes in brain activity and blood flow after stroke.

Study Type

INTERVENTIONAL

Allocation

Purpose

DEVICE_FEASIBILITY

Masking

NONE

Enrollment

Conditions

Stroke

Interventions

Combined EEG and fNIRSDEVICE

The EEG+NIRS recordings will be obtained via an extended EEG cap that is applied to the subject's head. Changes in neuronal activity and hemodynamics will be measured. The EEG component is the microEEG by BioSignal Group, UA. The fNIRS component is the NIRScout 24x32, NIRx Medizintechnik GmbH, Germany

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients with a subacute ischemic stroke with symptom onset within 8 weeks * Must have a measurable deficit on the National Institute of Health Stroke Scale (NIHSS) * Able to give and sign informed consent Exclusion Criteria: * Aphasia * Underlying dementia * Any chronic neurological disorder * Malignancy * Non-ambulatory (ambulation with assistance will be included) * Modified Rankin Score (mRS) \> 3

Locations (1)

The University of Texas Health Science Center at Houston

Houston, Texas, United States

Outcomes

Primary Outcomes

Number of participants with abnormal blood flow as assessed by fNIRS

Abnormal blood flow is determined by comparing a part of the patient's brain not affected by stroke to a part of the patient's brain affected by stroke.

Time frame: immediately at the time of combined EEG and fNIRS for up to 60 minutes

Number of participants with abnormal neuronal activity as assessed by EEG

Abnormal neuronal activity is determined by comparing a part of the patient's brain not affected by stroke to a part of the patient's brain affected by stroke.

Time frame: immediately at the time of combined EEG and fNIRS for up to 60 minutes

Data from ClinicalTrials.gov

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