Several studies have demonstrated that D2 treatment is associated with a decrease in 25(OH)D3 level and therefore have proposed that D3 would be preferable in term of raising total 25(OH)D level. The investigators postulate that the D2 treatment-associated decrease in 25(OH)D3 level may be related to an increase in total 25(OH)D level rather than being specific to D2 treatment, and thus there would be a D3 treatment-associated decrease in 25(OH)D2 level. The investigators plan to conduct a double-blind placebo-controlled trial to examine the effect of D3 treatment on 25(OH)D2 level and the effect of D2 treatment on 25(OH)D3 leve
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
100
Single oral dose of 50,000 IU of vitamin D3
Single oral dose of 50,000 IU of vitamin D2
Placebo oral capsule
King Faisal Specialist Hospital & Research Center
Riyadh, Central, Saudi Arabia
ANCOVA-adjusted, mean D2-induced change in 25(OH)D3 level group-1
Time frame: day 28
ANCOVA-adjusted, mean D3-induced change in 25(OH)D2 level in group-2
Time frame: day 28
ANCOVA-adjusted, mean D2-induced change in 25(OH)D3 level group-1
Time frame: day 56
ANCOVA-adjusted, mean D3-induced change in 25(OH)D2 level in group-2
Time frame: day 56
Pearson correlation between changes in 25(OH)D3 level in the active arm of group-1 and baseline total 25(OH)D level
Time frame: day 28
Pearson correlation between changes in 25(OH)D2 level in the active arm of group-2 and baseline total 25(OH)D level
Time frame: day 28
Pearson correlation between changes in 25(OH)D3 level and 25(OH)D2 level in the active arm of each group
Time frame: day 28
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