Effect of Topical Trimebutine on Pain After Hemorrhoidectomy

Mansoura University42 enrolled

Overview

Trimebutine acts through smooth muscle relaxation. It is presumed that the topical application of trimebutine after hemorrhoidectomy may help relieve pain after the procedure by relaxing the internal anal sphincter spasm.

A randomized trial will be carried out to investigate the effect of trimebutine on pain after Milligan-Morgan hemorrhoidectomy. Trimebutine relaxes the internal anal sphincter spasm which usually occurs after excisional hemorrhoidectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Hemorrhoids

Interventions

TrimebutineDRUG

Trimebutine suppository will be inserted in the anal canal on completion of hemorrhoidectomy then at six and 12 hours postoperatively.

HemorrhoidectomyPROCEDURE

Patients will undergo classic Milliagn-Morgan hemorrhoidectomy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of both genders aging between 18-70 years with grade III/VI internal hemorrhoids will be included Exclusion Criteria: * Patients with grade I/II internal hemorrhoids or external hemorrhoids. * Patients with associated anorectal pathology such as anal fissure, anal fistula, rectal prolapse, neoplasm, solitary rectal ulcer, and inflammatory bowel diseases.\\ * Patients with recurrent hemorrhoids after previous surgery.

Locations (1)

Mansoura university hospital

Al Mansurah, Dakahlia Governorate, Egypt

Outcomes

Primary Outcomes

Pain assessment assessed using visual analogue score from 0-10

Anal pain will be assessed using visual analogue score from 0-10

Time frame: Pain will be assessed at 12 hours after the procedure

Data from ClinicalTrials.gov

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