Pharmacokinetics of Epinephrine During Cardiac Arrest

Haukeland University Hospital8 enrolled

Overview

To determine the pharmacokinetics of epinephrine during cardiac arrest.

The aim of out study is to determine the pharmacokinetics in humans during cardiac arrest, following a single dose of epinephrine. Venous samples will be withdrawn every minute the first five minutes following a single dose. The aim of the study is to determine T1/2 in a clinical setting and to determine time to peak concentration.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Arrest

Interventions

EpinephrineDRUG

This is truly an observational study to determine T1/2 for epinephrine and time to peak concentration following a single dose of epinephrine in a cardiac arrest setting

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-85 yrs * Witnessed non-traumatic cardiac arrest. * Probable cardiac origin * Treated by Bergen Emergency Medical Services Exclusion Criteria: * Terminal illness * Residents of nursery homes * Obvious dead * Hypothermic patients * Epinephrine administered before arrival of study physician

Locations (1)

Haukeland University Hospital

Bergen, N, Norway

Outcomes

Primary Outcomes

Concentration of epinephrine (ng/mL) as a function of time the first five minutes following administration

Blood concentration of epinephrine will be determined the first five minutes following administration. For every minute starting With administration of epinephrine, blood samples will be drawn to determine the concentration (ng/mL). In total, six samples will be drawn. The administered dose (1 mg) will also be related to the patients weight, either estimated, or for those survivors admitted to hospital, measured in the Intensive Care Unit. Further, data according to the Utstein-template will be recorded.However, the primary outcome is to determine the plasma concentrations in every patients the first five minutes.

Time frame: Blood samples will be drawn within minutes, and the survivors transported to hospital. The data according to Utstein-style, will also be collected. Blood samples will be analysed within weeks.Total timeframe for the study is estimated to one year.

Data from ClinicalTrials.gov

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