Effect of Concurrent Capecitabine-based Long-term Radiotherapy Followed by XELOX Plus TME in Patients With High Risk Rectal Cancer: a Multi-centers, Randomized Controlled, Open-Label Trial

Inclusion Criteria: 1. Age of 18-75 years; 2. Histologically confirmed adenocarcinoma; 3. The rectal adenocarcinoma 0-12cm from the anal margin on Magnetic resonance imaging (MRI) and/or rigid sigmoidoscopy; 4. High risk of rectal cancer defined by high-resolution MRI: tumor invasion 5mm beyond the muscularis propria, or extramural vascular invasion, or circumferential resection margin unsafe, or the lower rectal cancer invades intersphincteric space, or rectal cancer invades the adjacent structures. 5. Eastern Collaborative Oncology Group performance status score of 0 or 2 6. Able and willing to give informed consent to participate. Exclusion Criteria: 1. Received preoperative chemoradiotherapy for rectal cancer before the recruitment of this study; 2. Have metastatic disease (including non-regional lymph nodes metastases or resectable liver metastases); 3. Other malignancies, non-adenocarcinoma rectal malignancies or rectal malignancies on the basis of inflammatory bowel disease; 4. Emergency surgery due to bowel obstruction, perforation, bleeding, etc.; 5. Abnormality of capecitabine absorption due to gastrointestinal disease e.g. short bowel syndrome, inflammation bowel disease, et al.; 6. Unresectable concurrent intestinal lesions; 7. Concurrent severe infection； 8. Cardiac Disease：uncontrolled or symptomatic cardiac angina，or uncontrolled arrhythmias and hypertension, or severe congestive heart failure grade II or more based on New York Heart Association (NYHA); myocardial infarction within the past 12 months 9. Peripheral neuropathy more than grade 1 according to the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE; version 3·0) 10. Bone marrow, liver and kidney function are abnormal e.g., white blood cell ≤ 1.5 × 109 / L; platelet ≤ 100 × 109 / L; Haemoglobin ≤ 80 g/L; Bilirubin \> 1.5 times the upper limit; aspartate aminotransferase and alanine aminotransferase \> 2.5 times the upper limit; creatinine \> 1.5 times the upper limit; 11. Pregnant or lactating women; 12. Life prediction less than 3 months, other severe diseases; 13. Contraindication to MRI; e.g. non-MRI compatible hip prosthesis, cardiac pacemaker; 14. Contraindication to standard chemotherapy including drug interactions and glomerular filtration rate \<50 mL/min at baseline; 15. Participators who had been recruited by other clinical trial within three months.