To investigate whether an oral nutritional supplement of a mixture of arginine, glutamine and HMB for a maximum period of four weeks is more beneficial than the standard dietary approach to the healing of pressure ulcers, and to examine whether the use of it can reduce admissions and length of hospitalizations for these patients.
All patients would be assessed by a dietitian to ensure them receiving nutritional support of at least 30 kcal/kg/day and of at least 1.2 g/kg/day of protein regardless of feeding method. During the study period, vitamin C and zinc supplement would not be given. Nutritional supplement other than that provided by the dietitian to meet the energy and protein requirement would not be given. The pressure ulcers would be cared according to the "Basic nursing standards for patient care: Wound dressing - Version 5" published by the Hospital Authority Head Office. The treatment group would also be given 2 Sackets of a mixture of arginine, glutamine and HMB (ABOUND) every day for a maximum period of 4 weeks, either orally or via enteral feeding.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
90
an oral mixture of arginine, glutamine and beta-hydroxy-beta-methylbutyrate
Our Lady of Maryknoll Hospital
Wong Tai Sin, Hong Kong
RECRUITINGpercentage change in pressure ulcer area
Time frame: 4 weeks
change in Pressure Ulcer Scale for Healing (PUSH)
Time frame: 4 weeks
number of hospital admissions
Time frame: six months
length of hospitalisation
Time frame: six months
Ka Ying Doris Miu, FHKAM (Med)
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