Assessing How Normal Variations in CT Scanning Affects Its Interpretation

N/AActive Not RecruitingNCT03038568

Memorial Sloan Kettering Cancer Center169 enrolled

Overview

The purpose of the study is to see how measurements of tumor differences vary with slight changes in CT scan parameters. Reproducible radiomic features can be extracted for abdominal tumors, and specifically colorectal liver metastases, imaged with clinical CT scanners even in the setting of variable scan parameters and variable contrast timing. Participants will be consented to undergo an additional CT of their abdomen.

Study Type

OBSERVATIONAL

Enrollment

169

Conditions

Colorectal Cancer Metastatic

Interventions

CT scanDIAGNOSTIC_TEST

Patients with colorectal liver metastases scheduled for abdominopelvic CECT will be consented to undergo an additional CT of their abdomen (termed add-on CT) within 15 seconds, before or after, their clinical portal venous phase CT (PV CT), which is performed at a fixed delay of 80 seconds at our institution.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients ≥ 18 years of age on the day of signed informed consent * Patients scheduled and approved for contrast enhanced CT that includes imaging of the abdomen and pelvis following the Department of Radiology standard of care protocol as per local institutional guidelines * Patients with measurable colorectal liver metastases on prior imaging, with at least one tumor greater than 2.0 cm in axial maximal diameter Exclusion Criteria: * Patient who is pregnant and/or lactating * Patient scheduled for CT that includes the abdomen with a multiphasic contrast enhanced protocol (e.g. Triple Phase or Quadruple Phase Liver CT) * Patient who require reduced intravenous contrast dose based on the Department of Radiology contrast policy as per local institutional guidelines * Any other medical condition, including mental illness or substance abuse, deemed by the Investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or follow up procedures

Locations (2)

Memorial Sloan Kettering Cancer Center

New York, New York, United States

MD Anderson Cancer Center, Texas (Data collection only)

Houston, Texas, United States

Outcomes

Primary Outcomes

assess the stability (reproducibility) of radiomic measurements obtained from repeat abdominal CT scans

There will be 18 cohorts, each cohort differing by the length of the time gap in acquisition and noise index. In addition each acquisition will be reconstructed in 21 different ways (combinations of 3 slice thicknesses and 7 ASiR levels).

Time frame: 2 years

Data from ClinicalTrials.gov

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