Vertical Transmission of Hepatitis C in Adult Children of Female Baby Boomers

University of Pennsylvania100 enrolled

Overview

The investigators aim to determine the prevalence of hepatitis C in the adult children of female baby boomers. During the years baby boomers were becoming pregnant, hepatitis C testing was either not available or was not standard of care. Because of this, participants' children may be unaware of participants' risk of hepatitis C.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Hepatitis C Hepatitis C, Chronic

Interventions

Eligibility ScreeningOTHER

Investigators will call eligible mothers to screen for the possibility that eligible mothers may have passed HCV on to adult children. Investigators will consent these mothers to contact the adult child(ren), as the child(ren) must be informed of the mother's HCV status, if not already known.

HCV testDIAGNOSTIC_TEST

Adult children will be invited to Penn or a Penn affiliate to have labwork, testing HCV antibody and HCV quant. If the quant comes back positive, investigators will also test genotype and fibrosure.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 72 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Mothers: * Born between 1/1/45-12/31/64 * Black or white race * Active or prior infection with hepatitis C * Have at least one living adult child over the age of 18 Children: * ≥18 years of age * Born to mother with current or prior HCV infection, with likely timing of HCV acquisition prior to or during pregnancy * Mother gave informed consent for child to be approached for study participation Exclusion Criteria: Mothers: \- Unwilling to disclose hepatitis C status to children

Locations (1)

Perelman Center for Advanced Medicine

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

HCV prevalence

Prevalence of HCV in adult children of female baby boomers who have or have had HCV

Time frame: Within 1 week of labwork at first study visit

Secondary Outcomes

Liver fibrosis

Level of liver fibrosis (detected through fibrosure test) found in adult children diagnosed as HCV-positive

Time frame: Within 2 weeks of diagnosis of HCV

HCV genotype

HCV genotype for adult children diagnosed as HCV-positive

Time frame: Within 6 weeks of diagnosis of HCV

Data from ClinicalTrials.gov

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