Postoperative Cesarean Delivery Pain Relief; Diclofenac Versus Bupivacaine

Department of Medical Services Ministry of Public Health of Thailand120 enrolled

Overview

This randomized controlled trial, compared postoperative pain score in patient undergoing cesarean delivery between bupivacaine peritoneal and subcutaneous infiltration and diclofenac intramuscular injection

Postoperative cesarean delivery was painful that can effect daily activity, resulted in poor quality of life and required morphine injection to relief pain which had both maternal and breastfeeding infancy side effect. So this study compare efficacy of diclofenac and bupivacaine by measured the pain score and requirement of morphine injection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

120

Conditions

Cesarean Delivery

Interventions

BupivacaineDRUG

0.5% bupivacaine 20ml divided in two; 10 ml intraperitoneal infiltration and 10 ml subcutaneous infiltration

DiclofenacDRUG

diclofenac 75 mg intramuscular, 2 hours postoperation

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergo elective or urgency cesarean delivery at Rajavithi Hospital in 2016-2017 * Urgency conditions: CPD, fail induction of labor, antepartum hemorrhage without hypovolemic shock, dystocia, previous cesarean section and active labor, malpresentation in labor, macrosomic presentation in labor * Pregnant women more than 20 years of age * Gestational age more than 37 week * Cesarean section under regional or general anesthesia * Ability to communicating, writing and reading Thai language Exclusion Criteria: * Inability to communicating or writing or reading Thai language * Contraindicated to bupivacaine or diclofenac or morphine * Pregnant women with emergency conditions * Have one or more complication of pregnancy * Intraoperative arrhythmia * Pregnant women less than 20 years of age * Regional anesthesia with morphine

Locations (2)

Natthida Mekwongtrakarn

Bangkok, Thailand

Rajavithi Hospital

Bangkok, Thailand

Outcomes

Primary Outcomes

Compared pain score change from baseline at 2, 6 and 24 hours at post-operation between 2 groups by visual analogue scale

Time frame: 2, 6 and 24 hours post-operation

Compared rescued dose of morphine injection

Time frame: Within 24 hours post-operation

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.