Xylitol and erythritol have become increasingly popular as sugar substitutes in the food industry. Both substances are freely available. While glucose ingestion stimulates satiation hormone secretion in the gut and slows down gastric emptying, artificial sweeteners such as aspartame, sucralose and acesulfame-K have no such effect. However, acute intake of 50g xylitol or 75g erythritol in 300mL tap water leads to a marked increase in the satiation hormones and induces a significant retardation in gastric emptying. The concentrations used to Show this effect were rather high (50g xylitol and 75g erythritol) and led to bloating and diarrhea in 60-70% of all subjects two hours after administration. The aim of the present study is to find an effective concentration of xylitol and erythritol still stimulating satiation hormone release without any gastrointestinal adverse events.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
24
Xylitol 7g in 300mL tap water
Erythritol 10g in 300mL tap water
Xylitol 17g in 300mL tap water
Xylitol 35g in 300mL tap water
Erythritol 25g in 300mL tap water
Erythritol 50g in 300mL tap water
University Hospital Basel
Basel, Switzerland
Acute effect on cholecystokinin ( CCK) release
effect on CCK release measured by a commercially available ELISA kit (enzyme-linked immunosorbent assay)
Time frame: changes from baseline to three hours after treatment
Acute effects on gastric emptying
Acute effects on gastric emptying measured by 13C-sodium-acetate breath test
Time frame: changes from baseline to three hours after treatment
Acute effects on subjective feelings of hunger and satiety
Acute effects on subjective feelings of hunger and satiety measured by visual analogue scales
Time frame: changes from baseline to three hours after treatment
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