Immunological Memory Induced by the 13valent Pneumococcal Conjugate(PCV13) and 23valent Plain Polysaccharide Vaccine(PPV23) in HIV-infected Patients

Aghia Sophia Children's Hospital of Athens40 enrolled

Overview

The purpose of this study is to determine the effect of a combined vaccination schedule of the 13-valent pneumococcal conjugate (PCV13) and 23valent plain polysaccharide vaccine (PPV23) on the establishment of immunological memory in HIV-infected adults on ART.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

HIV Infection

Interventions

PCV13BIOLOGICAL

PPV23BIOLOGICAL

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * CD4 T cell count \>200cells/μl * on ART Exclusion Criteria: * no previously recorded allergy to PCV, PPV23 * no intravenous immunoglobulin (IVIG) given within the previous 6 months * no other vaccine given within the previous 6 months

Outcomes

Primary Outcomes

immunoglobulin G (IgG) B memory cell response one month post vaccination (measured by flow cytometry)

Time frame: One month post-PCV13, PPV23

immunoglobulin M (IgM) B memory cell response one month post vaccination (measured by flow cytometry)

Time frame: One month post-PCV13, PPV23

Data from ClinicalTrials.gov

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