Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis

Meenakshi Ammal Dental College and Hospital75 enrolled

Overview

To assess the association between periodontal parameters, serum lipid profile and Lp-PLA2 level in systemically healthy Chronic Periodontitis subjects and healthy controls.

Seventy five participants were divided into 3 groups. The groups consisted of GROUP I- generalized severe chronic periodontitis, GROUP II- generalized moderate chronic periodontitis and GROUP III- systemically and periodontally healthy volunteers who served as control. The selected patients were then evaluated for periodontal parameters, lipid profile and Lp-PLA2.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Periodontitis (Disorder)

Interventions

serum lipid levels and Lp-PLA2DIAGNOSTIC_TEST

Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis

Eligibility

Sex: ALLMin age: 35 YearsMax age: 64 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Group I: 1. Subjects with age ≥ 35 years. 2. Presence of at least 24 teeth, with Clinical attachment loss (CAL) ≥ 5mm in more than 30% of sites. Group II: 1. Subjects with age ≥ 35 years. 2. Presence of at least 24 teeth, with Clinical attachment loss (CAL) between 3-4 mm in more than 30% of sites. Group III: 1. Subjects with age ≥ 35 years. 2. Healthy and intact periodontium Exclusion Criteria: 1. Presence of any systemic disease or conditions that could affect periodontal tissues. 2. History of periodontal treatment in past 6 months. 3. Smoking and alcoholism 4. Anomalies of blood and immune system 5. Systemic medication or antibiotic treatment for the previous 6 months. 6. Pregnant females.

Outcomes

Primary Outcomes

Estimation of serum Lp-PLA2

Serum Lp-PLA2 was estimated in all the groups using ELISA

Time frame: 9 months

Secondary Outcomes

Estimation of serum lipid profile

Serum Total cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein and very low density lipoprotein

Time frame: 9 months

Data from ClinicalTrials.gov

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