Surveillance Study for Early Detection of Cholangiocarcinoma (CCA) in Primary Sclerosing Cholangitis (PSC)

Karolinska University Hospital620 enrolled

Overview

This observational study of a national cohort of 600 Swedish PSC patients include yearly MR/MRCP, biobanking of serum, plasma and blood, followup clinical data (interventions, symptoms, labs, colonoscopy). The aim is to collect a well characterized cohort of PSC patients and provide future possibilities to evaluate biomarkers for prognosis and early cancer detection.

Study Type

OBSERVATIONAL

Enrollment

620

Conditions

Primary Sclerosing Cholangitis Cholangiocarcinoma

Interventions

MR/MRCPDIAGNOSTIC_TEST

MR/MRCP

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of PSC by MR/MRCP * Life expectancy \>1 year * Informed consent Exclusion Criteria: * Liver transplantation or on the waiting list * Secondry SC * Diagnosis of CCA

Locations (1)

Karolinska University Hospital, Huddinge

Stockholm, Sweden

Outcomes

Primary Outcomes

cholangiocarcinoma

Time frame: 10 yrs f-up

liver transplatation

Time frame: 10 yrs f-up

death

Time frame: 10 yrs f-up

Secondary Outcomes

biliary dysplasia

Time frame: 10 yrs f-up

Data from ClinicalTrials.gov

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