Previous studies have already revealed the involvement of the serotoninergic system in the social behavior process. For example, more serotonin (5HT) was found in dominant male adult monkeys. Little is known about the serotoninergic implication in human's social behavior. The project aims to clarify the role of the serotoninergic system in social behavior in relation to the process of social hierarchical information. In order to determine how serotoninergic system is involved, the investigator will use a new technic TEP-fMRI. This technic allows us to measure the brain activity and the serotoninergic transporter occupancy (using the \[C11\]-DASB) at the same time. The current study aims to investigate whether serotonin transporter (5-HTT) activity correlates with the neural response (BOLD) during the detection of social dominance in facial expressions or other measures of social information processing. Blood sample, SLC6A4 (allele coding for the 5HT transporter) genotyping and neuropsychological questionnaires will give at the investigator more information and allow to investigate whether performance on social information processing is modulated by personality trait and genotype.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
34
fMRI scan include MR sequences: BOLD and fMRI. The PET acquisition will be carried out in dynamic for 90 consecutive minutes following intravenous administration of 4 MBq / kg dose of \[11C\]DASB bolus.
Hospices Civils de Lyon
Bron, France
level of Blood-Oxygen-Level Dependent (BOLD) signal
The BOLD signal will be measured using a MRI scanner, and simultaneously we will record the level of serotonin transporter with \[11C\]DASB marker of the serotonin transmission, using a PET signal. We will use the Scatchard method in order to determine the level of \[11C\]DASB bonded to the transporter. Our reference region will be the cerebellum.
Time frame: at day 0
level of serotonin transporter
The BOLD signal will be measured using a MRI scanner, and simultaneously we will record the level of serotonin transporter with \[11C\]DASB marker of the serotonin transmission, using a PET signal. We will use the Scatchard method in order to determine the level of \[11C\]DASB bonded to the transporter. Our reference region will be the cerebellum.
Time frame: at day 0
Behavioral assessment
During the entire scanner, subjects will be ask to perform a behavioral task. Their responses will be analyzed.
Time frame: at day 0
Testosterone Blood level
The testosterone will be measured on a blood sample.
Time frame: after the scan session at day 0
Cortisol Blood level
The cortisol will be measured on a blood sample (prelevated at same time than testosterone).
Time frame: after the scan session at day 0
SLC6A4 genotyping
The genotyping of this gene (SLC6A4) will be realized on a sample of saliva.
Time frame: at day 0
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