HIT in Insulin-resistant and Insulin-sensitive Obese Adolescents

Faculdade de Ciências Médicas da Santa Casa de São Paulo25 enrolled

Overview

Evaluate the effects of HIT on the cardiorespiratory performance and substrate oxidation of insulin-resistant and insulin-sensitive obese adolescents.

Objective: To evaluate the effect of high-intensity interval training (HIT) on the cardiorespiratory performance and substrate oxidation pattern in insulin-resistant and insulin-sensitive obese adolescents.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Obesity Insulin-resistant Adolescents

Interventions

Group Insulin-ResistantOTHER

High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.

Group Insulin-SensitiveOTHER

High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.

Eligibility

Sex: ALLMin age: 12 YearsMax age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Criteria Inclusion Criteria: * aged 12-16 years * with a body mass index z-score (zBMI) ≥ + 2SD * puberty stage \> 3 * the boys and girls had to present a minimum physical fitness, according to the International Physical Activity Questionnaire (IPAQ), according to the activity performed during the last week and confirmed this using the peak cardiopulmonary test (VO2). Exclusion Criteria: * individuals undergoing drug treatment for weight control; * indiviudals who had cardiac, orthopedic, respiratory or renal problems, diabetes, uncontrolled hypertension, genetic syndrome or hormonal abnormalities.

Locations (3)

Santa Casa of Sao Paulo School

São Paulo, Brazil

Emef Angelina Maffei Vita

São Paulo, Brazil

Emef Plinio Queroz

São Paulo, Brazil

Outcomes

Primary Outcomes

rate of Peak oxygen consumption (VOpeak)

The cardiopulmonary test protocol for determination the VOpeak (ml/kg/min) included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion. We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil).

Time frame: 4 weeks

rate of Intensity at first ventilatory anaerobic threshold (VAT1)

The cardiopulmonary test protocol included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion. We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil).We determined VAT1 (ml/kg/min) using the V-slope method of Beaver et al.

Time frame: 4 weeks

rate of Peak Heart rate

The cardiopulmonary test protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil). speed of 4 km / h with increments of 1 km / h every minute until the participant shows exhaustion.

Time frame: 4 weeks

rate of carbohydrate oxidation

The substrate oxidation pattern protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil),during continuous exercise of submaximal intensity (45 minutes of treadmill running at the intensity of the first ventilatory anaerobic threshold).

Time frame: 4 weeks

rate of lipid oxidation

Time frame: 4 weeks

Data from ClinicalTrials.gov

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