Comparison Between Low Dose and High Dose Intra-articular Tranexamic Acid in Total Knee Arthroplasty

Thammasat University80 enrolled

Overview

The purpose of this study is to compare blood loss between using low dose (500 mg) and high dose (3 g) topical intra-articular tranexamic acid after total knee arthroplasty in double-blind RCT

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Blood Loss, Surgical

Interventions

Tranexamic AcidDRUG

IA (intra-articular) tranexamic acid after capsule closure

Eligibility

Sex: ALLMin age: 50 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Osteoarthritic knee who underwent primary total knee arthroplasty Exclusion Criteria: * Abnormal coagulation or bleeding disorder * Allergy to tranexamic acid * History of thromboembolism or ischemic heart disease or cerebrovascular accident * chronic kidney disease stage 3-4

Locations (1)

Thammasat University

Klong Luang, Changwat Pathum Thani, Thailand

Outcomes

Primary Outcomes

Total blood loss

Blood loos that calculated from Haemoglobin drop at 72 hours after surgery

Time frame: 72 hours after TKA

Secondary Outcomes

Blood transfusion

incidence of blood transfusion after surgery

Time frame: 0-72 hours after surgery

Rate of participants with thromboembolism

Clinical thromboembolism after surgery

Time frame: At 72 hours and 2 weeks after surgery

Rate of participants with infection

Superficial or deep infection after TKA

Time frame: 0-3 months after surgery

Knee ROM

Range of motion of the knee

Time frame: At 2, 6 weeks after surgery

Functional score

Modified WOMAC

Time frame: At 6 weeks after surgery

Data from ClinicalTrials.gov

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